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E-cadherin antibody
Category:
Research Area:
Synonyms: | Arc 1 antibody, Cadherin 1 antibody, CD324 antibody, CDH1 antibody, CDHE antibody, E cadherin antibody, ECAD antibody, E-cadherin antibody, LCAM antibody, UVO antibody, Uvomorulin antibody | ||
Catalogue No.: | FNab02618 | Reativity: | Human, Mouse, Rat |
Host: | Rabbit | Tested Application: | ELISA, IHC, WB |
Clonality: | polyclonal | Isotype: | IgG |
- SPECIFICATIONS
- Product Name
- E-cadherin antibody
- Catalogue No.
- FNab02618
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- cadherin 1, type 1, E-cadherin (epithelial)
- Alternative Names
- Arc 1 antibody, Cadherin 1 antibody, CD324 antibody, CDH1 antibody, CDHE antibody, E cadherin antibody, ECAD antibody, E-cadherin antibody, LCAM antibody, UVO antibody, Uvomorulin antibody
- UniProt ID
- P12830
- Observed MW
- 130 kDa
Application
- Tested Applications
- ELISA, IHC, WB
- Recommended dilution
- WB: 1:500 - 1:1000; IHC: 1:50 - 1:200
Validated Images
mouse testis tissue were subjected to SDS PAGE followed by western blot with FNab02618(E-cadherin antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab02618( E-cadherin Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Immunofluorescent analysis of (10% Formaldehyde ) fixed A431 cells using FNab02618 (E-cadherin Antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)
- Background
- This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.