Products
Connexin-43 antibody
- Product Name
- Connexin-43 antibody
- Catalogue No.
- FNab01861
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- gap junction protein, alpha 1, 43kDa
- Alternative Names
- Connexin-43 antibody, CX43 antibody, DFNB38 antibody, Gap junction alpha 1 protein antibody, GJA1 antibody, GJAL antibody, ODDD antibody
- UniProt ID
- P17302
- Observed MW
- 47 kDa
Application
- Tested Applications
- ELISA, WB, IHC, FC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:50-1:500
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab01861(GJA1 antibody) at dilution of 1:1000
IP Result of anti-Connexin-43 (IP: FNab01861, 4ug; Detection: FNab01861 1:1000) with mouse heart tissue lysate 3200ug.
Immunohistochemistry of paraffin-embedded mouse heart using FNab01861(GJA1 antibody) at dilution of 1:100
Immunofluorescent analysis of ( -20℃ Ethanol ) fixed HeLa cells using FNab01861 at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- Background
- Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract(By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles(By similarity).
