human heart tissue were subjected to SDS PAGE followed by western blot with FNab01846(COL6A1 Antibody) at dilution of 1:600
IP Result of anti-Collagen Type VI (IP: FNab01846, 4ug; Detection: FNab01846 1:500) with mouse heart tissue lysate 8000ug.
Immunohistochemistry of paraffin-embedded human kidney using FNab01846(COL6A1 antibody) at dilution of 1:100
Background
Type VI Collagen is a major structural component of microfibrils. Type VI Collagen was found to be present throughout the connective tissue and in the extracellular matrix of cultured fibroblasts(PMID: 6723253). It is a heterotrimer composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-5(VI) or alpha-6(VI). The alpha-1(VI) chain is encoded by COL6A1 gene. Mutations in this gene result in Bethlem myopathy and Ullrich congenital muscular dystrophy.