HeLa cells were subjected to SDS PAGE followed by western blot with FNab01657(CHMP1B antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse kidney using FNab01657(CHMP1B antibody) at dilution of 1:50
Background
CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).