Products
Cdc20 antibody
- Product Name
- Cdc20 antibody
- Catalogue No.
- FNab01518
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- cell division cycle 20 homolog
- Alternative Names
- CDC20 antibody, CDC20A antibody, p55CDC antibody
- UniProt ID
- Q12834
- Observed MW
- 55 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:500-1:1000; IP: 1:200-1:1000
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab01518( CDC20 Antibody) at dilution of 1:800
IP Result of anti-CDC20 (IP:FNab01518, 4ug; Detection:FNab01518 1:800) with Jurkat cells lysate 3200ug.
- Background
- Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome(APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
