Products

CD22 antibody

Synonyms:B cell receptor CD22 antibody, BL CAM antibody, CD22 antibody, CD22 molecule antibody, SIGLEC 2 antibody, SIGLEC2 antibody, T cell surface antigen Leu 14 antibody
Catalogue No.:FNab01444Reativity:Human
Host:MouseTested Application:ELISA, WB, IHC
Clonality:monoclonalIsotype:IgG1
  • SPECIFICATIONS
Product Name
CD22 antibody
Catalogue No.
FNab01444
Size
100μg
Form
liquid
Purification
Protein A+G purification
Purity
≥95% as determined by SDS-PAGE
Clonality
monoclonal
Isotype
IgG1
Clone ID
7D10
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
CD22 molecule
Alternative Names
B cell receptor CD22 antibody, BL CAM antibody, CD22 antibody, CD22 molecule antibody, SIGLEC 2 antibody, SIGLEC2 antibody, T cell surface antigen Leu 14 antibody
UniProt ID
P20273
Observed MW
135 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB : 1:1000-1:10000; IHC : 1:500-1:2000
Validated Images
Raji cells were subjected to SDS PAGE followed by western blot with FNab01444(CD22 antibody) at dilution of 1:5000
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab01444(CD22 Antibody) at dilution of 1:400
Background
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.