Products
Caspase 10 antibody
- Product Name
- Caspase 10 antibody
- Catalogue No.
- FNab01285
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- caspase 10, apoptosis-related cysteine peptidase
- Alternative Names
- ALPS2 antibody, Apoptotic protease Mch 4 antibody, CASP 10 antibody, CASP10 antibody, Caspase 10 antibody, Caspase 10/p23/17/p12 antibody, Caspase10 antibody, FLICE2 antibody, ICE like apoptotic protease 4 antibody, MCH4 antibody
- UniProt ID
- Q92851
- Observed MW
- 59kd
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab01285(CASP10 antibody) at dilution of 1:300
IP Result of anti-Caspase 10/p23/17/p12 (IP:FNab01285, 4ug; Detection:FNab01285 1:300) with HeLa cells lysate 3200ug.
Immunohistochemistry of paraffin-embedded human endometrial cancer using FNab01285(CASP10 antibody) at dilution of 1:100
- Background
- This gene encodes a protein which is a member of the cysteine-aspartic acid protease(caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
