BCCIP antibody

Synonyms:BRCA2 and CDKN1A-interacting protein|P21- and CDK-associated protein 1|Protein TOK-1|BCCIP|TOK1 antibody
Catalogue No.:FNab00832Reactivity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
BCCIP antibody
Catalogue No.
FNab00832
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
BRCA2 and CDKN1A interacting protein
Alternative Names
BRCA2 and CDKN1A-interacting protein|P21- and CDK-associated protein 1|Protein TOK-1|BCCIP|TOK1 antibody
UniProt ID
Q9P287
Observed MW
50 kDa
Application
Tested Applications
ELISA, WB, IHC
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:100 - 1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab00832(BCCIP antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human stomach using FNab00832(BCCIP antibody) at dilution of 1:100
Background
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.