Products
BACE1 antibody
- Product Name
- BACE1 antibody
- Catalogue No.
- FNab00781
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- beta-site APP-cleaving enzyme 1
- Alternative Names
- BACE antibody, KIAA1149 antibody
- UniProt ID
- P56817
- Observed MW
- 70-75 kDa
Application
- Tested Applications
- ELISA, WB, IP, IHC
- Recommended dilution
- WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:100-1:400
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00781(BACE1 antibody) at dilution of 1:500
IP Result of anti-BACE1 (IP:FNab00781, 3ug; Detection:FNab00781 1:500) with mouse brain tissue lysate 5000ug.
Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab00781(BACE1 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
- Background
- Responsible for the proteolytic processing of the amyloid precursor protein(APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
