Products

Alpha-2-macroglobulin antibody

Synonyms:A2M antibody, Alpha 2 M antibody, alpha 2 macroglobulin antibody, CPAMD5 antibody, DKFZp779B086 antibody, FWP007 antibody, S863 7 antibody, α-2M antibody
Catalogue No.:FNab00340Reativity:Human
Host:RabbitTested Application:ELISA, WB, IHC, IP
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
Alpha-2-macroglobulin antibody
Catalogue No.
FNab00340
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
alpha-2-macroglobulin
Alternative Names
A2M antibody, Alpha 2 M antibody, alpha 2 macroglobulin antibody, CPAMD5 antibody, DKFZp779B086 antibody, FWP007 antibody, S863 7 antibody, α-2M antibody
UniProt ID
P01023
Observed MW
185 kDa
Application
Tested Applications
ELISA, WB, IHC, IP
Recommended dilution
WB: 1:2000-1:20000; IP: 1:200-1:1000; IF: 1:50-1:500; IHC: 1:20-1:200
Validated Images
human blood tissue were subjected to SDS PAGE followed by western blot with FNab00340(A2M antibody) at dilution of 1:6000
IP Result of anti-Alpha-2-macroglobulin (IP:FNab00340, 5ug; Detection:FNab00340 1:500) with human plasma lysate 4000ug.
Immunohistochemistry of paraffin-embedded human hepatocirrhosis tissue slide using FNab00340(A2M Antibody) at dilution of 1:50
Background
Alpha-2-macroglobulin, also known as α2-macroglobulin(α2M or A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. A2M is an evolutionarily conserved arm of the innate immune system. It also mediates the proliferation of T cells and macrophages. A2M acts as a nonspecific protease inhibitor involved in the host defense mechanism that inactivates both endogenous and exogenous proteases, including trypsin, thrombin and collagenase. Even though A2M is produced predominantly by the liver, it may also be expressed in the reproductive tract, heart, and brain, and may have important roles in many physiological processes and medical illnesses including Alzheimer’s disease.