HeLa cells were subjected to SDS PAGE followed by western blot with FNab00328(GLA antibody) at dilution of 1:1000
IP Result of anti-Alpha galactosidase A (IP:FNab00328, 3ug; Detection:FNab00328 1:1000) with HEK-293 cells lysate 1800ug.
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab00328(GLA antibody) at dilution of 1:50
Background
GLA, also named as Melibiase, Agalsidas and Alpha-galactosidase A, Belongs to the glycosyl hydrolase 27 family. It hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids. Fabry disease is an X-linked lysosomal storage disorder resulting from the deficient activity of GLA. Enzyme replacement therapy(ERT) with GLA is currently the most effective therapeutic strategy for patients with Fabry disease, a lysosomal storage disease.