Products

anti- Alpha B Crystallin antibody

FNab00325 Catalogue No.
Synonyms
Alpha B Crystallin, Alpha crystallin B chain, Alpha(B) crystallin, CRYA2, CRYAB, crystallin, alpha B, CTPP2, Heat shock protein beta 5, HSPB5, Rosenthal fiber component
Host
Rabbit
Reactivity
Human, Mouse, Rat
Isotype
IgG
Tested Application
ELISA, WB, IHC, IP
Product Information
Product Name
anti- Alpha B Crystallin antibody
Catalogue No.
FNab00325
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Alpha B-crystallin, encoded by CRYAB gene, is multifunctional, serving as both a major structural protein in the lens and a small heat-shock protein in other tissues in mammals. Alpha B-crystallin may contribute to the transparency and refractive index of the lens. Single nucleotide polymorphisms(SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. Mutations in the CRYAB gene cause distinct clinical phenotypes including isolated posterior polar cataract, myofibrillar myopathy, cardiomyopathy, or a multisystemic disorder combining all these features. Impairment of alpha-B crystallin dimerization may be relevant to the pathogenesis of these disorders.
Immunogen Information
Immunogen
crystallin, alpha B
Synonyms
Alpha B Crystallin, Alpha crystallin B chain, Alpha(B) crystallin, CRYA2, CRYAB, crystallin, alpha B, CTPP2, Heat shock protein beta 5, HSPB5, Rosenthal fiber component
Observed MW
20 kDa
Application
Tested Application
ELISA, WB, IHC, IP
Recommended dilution
WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:2000
Uniprot information
UniProt ID
P02511
Images
IP Result of anti-Alpha B Crystallin (IP:FNab00325, 3ug; Detection:FNab00325 1:500) with mouse heart tissue lysate 4000ug.
human heart tissue were subjected to SDS PAGE followed by western blot with FNab00325(CRYAB antibody) at dilution of 1:500