Products
Alpha B Crystallin antibody
- Product Name
- Alpha B Crystallin antibody
- Catalogue No.
- FNab00325
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- crystallin, alpha B
- Alternative Names
- Alpha B Crystallin antibody, Alpha crystallin B chain antibody, Alpha(B) crystallin antibody, CRYA2 antibody, CRYAB antibody, crystallin antibody, alpha B antibody, CTPP2 antibody, Heat shock protein beta 5 antibody, HSPB5 antibody, Rosenthal fiber component antibody
- UniProt ID
- P02511
- Observed MW
- 20 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:2000
Validated Images
human heart tissue were subjected to SDS PAGE followed by western blot with FNab00325(CRYAB antibody) at dilution of 1:500
IP Result of anti-Alpha B Crystallin (IP:FNab00325, 3ug; Detection:FNab00325 1:500) with mouse heart tissue lysate 4000ug.
- Background
- Alpha B-crystallin, encoded by CRYAB gene, is multifunctional, serving as both a major structural protein in the lens and a small heat-shock protein in other tissues in mammals. Alpha B-crystallin may contribute to the transparency and refractive index of the lens. Single nucleotide polymorphisms(SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. Mutations in the CRYAB gene cause distinct clinical phenotypes including isolated posterior polar cataract, myofibrillar myopathy, cardiomyopathy, or a multisystemic disorder combining all these features. Impairment of alpha-B crystallin dimerization may be relevant to the pathogenesis of these disorders.
