Products

anti- ABL2 antibody

FNab00053 Catalogue No
Synonyms
Abelson related gene protein, ABL2, ABLL, ARG, FLJ22224, FLJ31718, FLJ41441, Tyrosine protein kinase ABL2, Tyrosine protein kinase ARG
Host
Rabbit
Reactivity
Human, Mouse, Rat
Isotype
IgG
Application
ELISA, WB, IF, IHC, IP
Product Information
Product Name
anti- ABL2 antibody
Catalogue No.
FNab00053
Size
100µg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Background
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement) ; CTTN (involved in signaling) ; or TUBA1 and TUBB (microtubule subunits) . Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
Immunogen Information
Immunogen
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
Synonyms
Abelson related gene protein, ABL2, ABLL, ARG, FLJ22224, FLJ31718, FLJ41441, Tyrosine protein kinase ABL2, Tyrosine protein kinase ARG
Observed MW
127 kDa
Application
Tested Application
ELISA, WB, IF, IHC, IP
Recommended dilution
WB :1:500-1:5000; IHC: 1:20-1:200; IF: 1:10-1:100; IP: 1:200-1:2000
Uniprot information
Uniprot ID
P42684
Images
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab00053 (ABL2 Antibody) at dilution of 1:50
HeLa cells were subjected to SDS PAGE followed by western blot with FNab00053 (ABL2 antibody) at dilution of 1:500