Products
GNA13 antibody
- Product Name
- GNA13 antibody
- Catalogue No.
- FNab10935
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- guanine nucleotide binding protein (G protein), alpha 13
- Alternative Names
- G alpha 13 antibody, G protein subunit alpha 13 antibody, G13 antibody, GNA13 antibody
- UniProt ID
- Q14344
- Observed MW
- 44 kDa
Application
- Tested Applications
- WB, IHC, IF
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Validated Images
Various lysates were subjected to SDS PAGE followed by western blot with FNab10935(GNA13 Antibody) at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded human stomach using FNab10935(GNA13 Antibody) at dilution of 1:100
- Background
- Guanine nucleotide-binding proteins (G proteins are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG. GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1 (By similarity. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation.
