Products
GSDMD antibody
- Product Name
- GSDMD antibody
- Catalogue No.
- FNab10648
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 10D7
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- gasdermin D
- Alternative Names
- DF5L antibody, DFNA5L antibody, FKSG10 antibody, FLJ12150 antibody, gasdermin D antibody, GSDMD antibody, GSDMDC1 antibody
- UniProt ID
- P57764
- Observed MW
- 47-53 kDa
Application
- Tested Applications
- ELISA, WB, IF
- Recommended dilution
- WB: 1:1000-1:5000; IF: 1:20-1:200
Validated Images
Immunofluorescent analysis of Hela cells using FNab10648 (GSDMD antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-mouse IgG(H+L)
- Background
- GSDMD is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. GSDMD has been suggested to act as a tumor suppressor. Recently, GSDMD is identified as a new component of inflammasomes, and it is an executor of pyroptosis and required for interleukin-1β secretion. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.