mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab10486(SP1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded rat liver tissue slide using FNab10486(SP1 antibody) at dilution of 1:50
Background
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.