K562 cells were subjected to SDS PAGE followed by western blot with FNab10366(FZD4 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human kidney using FNab10366(FZD4 antibody) at dilution of 1:100
Background
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.