Immunohistochemistry of paraffin-embedded human kidney using FNab10074( RECK Antibody) at dilution of 1:100
Background
Negatively regulates matrix metalloproteinase-9(MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.