NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab09841 (DVL1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab09841( DVL1 antibody) at dilution of 1:200
Background
DVL1 is one of three DVL homologous proteins (DVL1–3) widely expressed in embryonic development and in the adult central nervous system. Dishevelled proteins are a necessary component of the Wnt and planar cell polarity developmental signaling pathways. Overexpression of DVL1 has been linked to prostate and breast cancers through the Wnt signaling pathway.