Products
ZNF238 antibody
- Product Name
- ZNF238 antibody
- Catalogue No.
- FNab09671
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- zinc finger protein 238
- Alternative Names
- 58 kDa repressor protein antibody, C2H2 171 antibody, RP58 antibody, TAZ 1 antibody, TAZ1 antibody, Transcriptional repressor RP58 antibody, ZBTB18 antibody, ZFP238 antibody, zinc finger protein 238 antibody, Zinc finger protein C2H2 171 antibody, ZNF238 antibody
- UniProt ID
- Q99592
- Observed MW
- 48 kDa
Application
- Tested Applications
- ELISA, WB, IP, IHC
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200
Validated Images
mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab09671(ZNF238 antibody) at dilution of 1:1000
IP result of anti-ZNF238 (FNab09671 for IP and Detection) with mouse cerebellum tissue.
Immunohistochemistry of paraffin-embedded mouse brain tissue slide using FNab09671(ZNF238 Antibody) at dilution of 1:50
- Background
- ZNF238 is a member of the BTB/POZ-ZF protein family, which involve in development and cancer formation, for example BCL-6, PLZF, and HIC-1. It's a transcriptional repressor involve in myogenesis and brain development. By directly repressing the expression of two skeletal myogenesis inhibitors, ID2 and ID3, ZNF238 plays a key role in myogenesis. It can control cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Besides, ZNF238 involves in the organization of nuclear chromosomes, for its specific binding to the consensus DNA sequence that contains the E box core, and recruiting chromatin remodeling multiportein complex. ZNF238 proteins has apparent molecular masses of 60 and 48 kD. Specific binding is found for a 60-kDa band which corresponds to the full length of RP58 protein. In addition, a 48-kDa band, thought to be the truncated form 2 is detected(PMID: 9756912).
