Products
ZIP8 antibody
- Product Name
- ZIP8 antibody
- Catalogue No.
- FNab09643
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- solute carrier family 39(zinc transporter), member 8
- Alternative Names
- BIGM103 antibody, PP3105 antibody, SLC39A8 antibody, ZIP 8 antibody, ZIP8 antibody
- UniProt ID
- Q9C0K1
- Observed MW
- 53 kDa, 75-90 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Validated Images
mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab09643(SLC39A8 antibody) at dilution of 1:800
IP Result of anti-ZIP8(IP: FNab09643 4μg; Detection: FNab09643 1:500) with mouse liver tissue lysate 5000 ug
Immunohistochemistry of paraffin-embedded human placenta using FNab09643(SLC39A8 antibody) at dilution of 1:100
Immunofluorescent analysis of HepG2 cells, using FNab09643(SLC39A8 antibody) at 1:25 dilution
- Background
- SLC39A8 also known as ZIP8 belongs to the ZIP family of metal ion transporters which function to transport zinc and/or other metal ion substrates from the extracellular space or organellar lumen into the cytoplasm. Recently it was found that Zip8 expression is upregulated in human monocytes in response to LPS, TNF-α, and live bacteria, facilitating cytoprotection during the early inflammation. Besides zinc ZIP8 can also transport cadmium and manganese efficiently. It is predicted that ZIP8 contains 3 potential N-linked glycosylation sites and is subject to glycosylation, which may account for the presences of multiple molecular weights, such as 43 kDa, 49 kDa, 60 kDa, 75-90 kDa, 150 kDa, and 200 kDa.
