Products
ZGPAT antibody
- Product Name
- ZGPAT antibody
- Catalogue No.
- FNab09634
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- zinc finger, CCCH-type with G patch domain
- Alternative Names
- ZGPAT antibody, ZC3HDC9 antibody, ZC3H9 antibody, KIAA1847 antibody, GPATCH6 antibody
- UniProt ID
- Q8N5A5
- Observed MW
- 57 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500-1:5000
Validated Images
L02 cells were subjected to SDS PAGE followed by western blot with FNab09634(ZGPAT antibody) at dilution of 1:1000
- Background
- Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.
