Products
ZFYVE19 antibody
- Product Name
- ZFYVE19 antibody
- Catalogue No.
- FNab09629
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- zinc finger, FYVE domain containing 19
- Alternative Names
- FLJ14840 antibody, MPFYVE antibody, ZFYVE19 antibody
- UniProt ID
- Q96K21
- Observed MW
- 52 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:1000-1:10000; IHC: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab09629(ZFYVE19 antibody) at dilution of 1:2000
Immunohistochemistry of paraffin-embedded human heart slide using FNab09629(ZFYVE19 Antibody) at dilution of 1:50
- Background
- Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4(VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
