Products
ZFP36L2 antibody
- Product Name
- ZFP36L2 antibody
- Catalogue No.
- FNab09625
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- zinc finger protein 36, C3H type-like 2
- Alternative Names
- BRF2 antibody, Butyrate response factor 2 antibody, EGF response factor 2 antibody, ERF 2 antibody, ERF2 antibody, Protein TIS11D antibody, RNF162C antibody, TIS11D antibody, ZFP36L2 antibody
- UniProt ID
- P47974
- Observed MW
- 51 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:200-1:2000
Validated Images
HepG2 cells were subjected to SDS PAGE followed by western blot with FNab09625(ZFP36L2 antibody) at dilution of 1:500
- Background
- mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element(ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation(PubMed:14981510). Specifically expressed in burst-forming unit-erythroid(BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation(By similarity).
