Products
ZCCHC6 antibody
- Product Name
- ZCCHC6 antibody
- Catalogue No.
- FNab09611
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- zinc finger, CCHC domain containing 6
- Alternative Names
- DKFZp666B142 antibody, DKFZp686C11112 antibody, DKFZp686F119 antibody, DKFZp686I1269 antibody, HS2 antibody, KIAA1711 antibody, PAPD6 antibody, Terminal uridylyltransferase 7 antibody, TUT7 antibody, TUTase 7 antibody, ZCCHC6 antibody
- UniProt ID
- Q5VYS8
- Observed MW
- 171 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:500-1:5000
Validated Images
PC-3 cells were subjected to SDS PAGE followed by western blot with FNab09611(ZCCHC6 Antibody) at dilution of 1:1000
IP Result of anti-ZCCHC6 (IP:FNab09611, 4ug; Detection:FNab09611 1:1000) with HeLa cells lysate 1800ug.
- Background
- Uridylyltransferase that mediates the terminal uridylation of mRNAs with short(less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay(PubMed:19703396, PubMed:25480299). Involved in microRNA(miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets(PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7(pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A(PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.
