Products
ZC3HC1 antibody
- Product Name
- ZC3HC1 antibody
- Catalogue No.
- FNab09608
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- zinc finger, C3HC-type containing 1
- Alternative Names
- ZC3HC1 antibody, 1110054L24Rik antibody, hNIPA antibody, HSPC216 antibody, NIPA antibody
- UniProt ID
- Q86WB0
- Observed MW
- 55 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:200-1:2000
Validated Images
mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab09608(ZC3HC1 antibody) at dilution of 1:500
- Background
- Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1(CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
