Products
ZBP1 antibody
- Product Name
- ZBP1 antibody
- Catalogue No.
- FNab09586
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- Z-DNA binding protein 1
- Alternative Names
- ZBP1 antibody, C20orf183 antibody, DLM1 antibody, Z DNA binding protein 1 antibody, DLM 1 antibody
- UniProt ID
- Q9H171
- Observed MW
- 66 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:20-1:200
Validated Images
Jurkat cells were subjected to SDS PAGE followed by western blot with FNab09586(ZBP1 antibody) at dilution of 1:400
Immunohistochemistry of paraffin-embedded human liver cancer using FNab09586(ZBP1 antibody) at dilution of 1:50
- Background
- Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor(IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3(By similarity).
