Products
XRN1 antibody
- Product Name
- XRN1 antibody
- Catalogue No.
- FNab09556
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- 5'-3' exoribonuclease 1
- Alternative Names
- 5 3 exoribonuclease 1 antibody, 5' 3' exoribonuclease 1 antibody, DKFZp434P0721 antibody, DKFZp686B22225 antibody, DKFZp686F19113 antibody, FLJ41903 antibody, SEP1 antibody, XRN1 antibody
- UniProt ID
- Q8IZH2
- Observed MW
- 192 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab09556(XRN1 antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human heart slide using FNab09556(XRN1 Antibody) at dilution of 1:50
- Background
- Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA(By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma(OGS).
