Products
WDR1 antibody
- Product Name
- WDR1 antibody
- Catalogue No.
- FNab09481
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- WD repeat domain 1
- Alternative Names
- Actin interacting protein 1 antibody, AIP1 antibody, NORI 1 antibody, WD repeat containing protein 1 antibody, WD repeat domain 1 antibody, WDR1 antibody
- UniProt ID
- O75083
- Observed MW
- 66 kDa
Application
- Tested Applications
- ELISA, IHC, IP, WB
- Recommended dilution
- WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200
Validated Images
rat skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab09481(WDR1 Antibody) at dilution of 1:600
IP Result of anti-WDR1 (IP:FNab09481, 3ug; Detection:FNab09481 1:500) with mouse skeletal muscle tissue lysate 3600ug.
Immunohistochemistry of paraffin-embedded human testis using FNab09481(WDR1 antibody) at dilution of 1:100
- Background
- Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins(PubMed:15629458). Enhances cofilin-mediated actin severing(By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions(PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance(By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity(PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension(By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt(PubMed:25792565).
