Products
VPS53 antibody
- Product Name
- VPS53 antibody
- Catalogue No.
- FNab09448
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- vacuolar protein sorting 53 homolog
- Alternative Names
- FLJ10979 antibody, HCCS1 antibody, hVps53L antibody, pp13624 antibody, VPS53 antibody
- UniProt ID
- Q5VIR6
- Observed MW
- 96 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:500-1:5000；IP: 1:200-1:2000
Validated Images
human liver tissue were subjected to SDS PAGE followed by western blot with FNab09448(VPS53 antibody) at dilution of 1:300
- Background
- Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network(TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD(PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor(TFRC) to the plasma membrane(PubMed:25799061).
