Products
VHL antibody
- Product Name
- VHL antibody
- Catalogue No.
- FNab09402
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- von Hippel-Lindau tumor suppressor
- Alternative Names
- HRCA1 antibody, Protein G7 antibody, pVHL antibody, RCA1 antibody, VHL antibody, VHL1 antibody, Von Hippe-Lindau antibody
- UniProt ID
- P40337
- Observed MW
- 18-24 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:20-1:200
Validated Images
293T cells were subjected to SDS PAGE followed by western blot with FNab09402(VHL antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human kidney using FNab09402(VHL antibody) at dilution of 1:50?
- Background
- Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor(HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
