Products
VAMP8 antibody
- Product Name
- VAMP8 antibody
- Catalogue No.
- FNab09365
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- vesicle-associated membrane protein 8(endobrevin)
- Alternative Names
- EDB antibody, Endobrevin antibody, VAMP 8 antibody, VAMP8 antibody
- UniProt ID
- Q9BV40
- Observed MW
- 15 kDa
Application
- Tested Applications
- ELISA, WB
- Recommended dilution
- WB: 1:200-1:1000
Validated Images
HL-60 cells were subjected to SDS PAGE followed by western blot with FNab09365(VAMP8 Antibody) at dilution of 1:300
- Background
- SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex(PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets(PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells(By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells(By similarity). Involved in the homotypic fusion of early and late endosomes(By similarity).
