Products
URM1 antibody
- Product Name
- URM1 antibody
- Catalogue No.
- FNab09289
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ubiquitin related modifier 1 homolog
- Alternative Names
- URM1 antibody, C9orf74 antibody
- UniProt ID
- Q9BTM9
- Observed MW
- 11 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:500-1:5000; IHC：1:20-1:200
Validated Images
human placenta tissue were subjected to SDS PAGE followed by western blot with FNab09289(URM1 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human liver cancer using FNab09289(URM1 antibody) at dilution of 1:100
- Background
- Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated(-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein(UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
