Products
uPAR antibody
- Product Name
- uPAR antibody
- Catalogue No.
- FNab09268
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- plasminogen activator, urokinase receptor
- Alternative Names
- CD87 antibody, MO3 antibody, PLAUR antibody, U PAR antibody, UPAR antibody, URKR antibody
- UniProt ID
- Q03405
- Observed MW
- 37-70 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:200-1:2000; IP: 1:200-1:1000
Validated Images
RAW264.7 cells were subjected to SDS PAGE followed by western blot with FNab09268(uPAR, PLAUR antibody) at dilution of 1:500
IP Result of anti-uPAR, PLAUR (IP:FNab09268, 4ug; Detection:FNab09268 1:300) with RAW 264.7 cells lysate 4000ug.
- Background
- Urokinase plasminogen activator surface receptor(uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains(D1-D3) of which the N-terminal one(D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator(uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis.(PMID 20027185; 12461559)
