Products
uPA antibody
- Product Name
- uPA antibody
- Catalogue No.
- FNab09267
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- plasminogen activator, urokinase
- Alternative Names
- ATF antibody, PLAU antibody, U plasminogen activator antibody, uPA antibody, URK antibody
- UniProt ID
- P00749
- Observed MW
- 54 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP, IF
- Recommended dilution
- WB: 1:500-1:1000; IHC：1:20-1:200；IF: 1：20-1：200; IP: 1：500-1：2000
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab09267(uPA antibody) at dilution of 1:500
IP Result of anti-uPA (IP:FNab09267, 4ug; Detection:FNab09267 1:1000) with HeLa cells lysate 2800ug.
Immunohistochemistry of paraffin-embedded human skin using FNab09267(uPA antibody) at dilution of 1:50
Immunofluorescent analysis of HeLa cells using FNab09267 (uPA antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
- Background
- PLAU(Urokinase-type plasminogen activator) is also named as uPA and belongs to the peptidase S1 family.UPA initiates a proteolytic cascade, which degrades extracellular matrix during tissue growth and remodelling.The secreted proform of UPA is activated after binding to a specific high affinity cell surface receptor. Secreted UPA is exposed to rapid inactivation in the pericellular space by plasminogen activator inhibitor-1(PAI-1), which is stored in the extracellular matrix bound to vitronectin(PMID:9665342).It has 2 isoforms produced by alternative splicing.Defects in PLAU are the cause of Quebec platelet disorder(QPD).
