Products
ULBP1 antibody
- Product Name
- ULBP1 antibody
- Catalogue No.
- FNab09249
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- UL16 binding protein 1
- Alternative Names
- ALCAN beta antibody, N2DL 1 antibody, N2DL1 antibody, NKG2D ligand 1 antibody, NKG2DL1 antibody, RAET1I antibody, UL16 binding protein 1 antibody, ULBP1 antibody
- UniProt ID
- Q9BZM6
- Observed MW
- 30 kDa, 37 kDa
Application
- Tested Applications
- ELISA, WB, IHC
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1：20-1：200
Validated Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab09249(ULBP1 antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human liver using FNab09249(ULBP1 antibody) at dilution of 1:50
- Background
- Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
