mouse thymus tissue were subjected to SDS PAGE followed by western blot with FNab09233( UFD1L Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using FNab09233( UFD1L Antibody) at dilution of 1:50
Background
The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18.