Products
UBR2 antibody
- Product Name
- UBR2 antibody
- Catalogue No.
- FNab09209
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ubiquitin protein ligase E3 component n-recognin 2
- Alternative Names
- BA49A4.1 antibody, C6orf133 antibody, dJ242G1.1 antibody, dJ392M17.3 antibody, DKFZp686C08114 antibody, KIAA0349 antibody, N recognin 2 antibody, RP3 392M17.3 antibody, UBR2 antibody
- UniProt ID
- Q8IWV8
- Observed MW
- 66 kDa
Application
- Tested Applications
- ELISA, WB, IF, IHC
- Recommended dilution
- WB: 1:200-1:2000; IF：1：10-1:100; IHC: 1:20-1:200
Validated Images
BxPC-3 cells were subjected to SDS PAGE followed by western blot with FNab09209(UBR2 antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human pancreas tissue slide using FNab09209(UBR2 Antibody) at dilution of 1:50
- Background
- E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
