Products
UBQLN2 antibody
- Product Name
- UBQLN2 antibody
- Catalogue No.
- FNab09205
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ubiquilin 2
- Alternative Names
- CHAP1 antibody, CHAP1/DSK2 antibody, Dsk2 antibody, DSK2 homolog antibody, hPLIC 2 antibody, HRIHFB2157 antibody, LIC 2 antibody, N4BP4 antibody, PLIC 2 antibody, PLIC2 antibody, RIHFB2157 antibody, ubiquilin 2 antibody, Ubiquilin-2 antibody, UBQLN2 antibody
- UniProt ID
- Q9UHD9
- Observed MW
- 70 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:20-1:200；IF：1:20-1:200
Validated Images
rat brain tissue were subjected to SDS PAGE followed by western blot with FNab09205(UBQLN2 antibody) at dilution of 1:800
Immunohistochemistry of paraffin-embedded human testis slide using FNab09205(UBQLN2 Antibody) at dilution of 1:50
- Background
- Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system(UPS), autophagy and the endoplasmic reticulum-associated protein degradation(ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding(via UBA domain) to their polyubiquitin chains and by interacting(via ubiquitin-like domain) with the subunits of the proteasome(PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome(PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion(PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits(CCPs)(PubMed:18199683).
