Products
UBA52 antibody
- Product Name
- UBA52 antibody
- Catalogue No.
- FNab09145
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- ubiquitin A-52 residue ribosomal protein fusion product 1
- Alternative Names
- UBA52 antibody, UBCEP2 antibody, HUBCEP52 antibody, CEP52 antibody, RPL40 antibody
- UniProt ID
- P62987
- Observed MW
- 118 kDa
Application
- Tested Applications
- ELISA, IHC
- Recommended dilution
- IHC: 1:20-1:200
Validated Images
Immunohistochemical of paraffin-embedded human kidney using FNab09145(UBA52 antibody) at dilution of 1:50?
- Background
- Ubiquitin: Exists either covalently attached to another protein, or free(unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer(monoubiquitin), a polymer linked via different Lys residues of the ubiquitin(polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin(linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD(endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free(unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.60S ribosomal protein L40: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.
