Products
Tuberin-Specific antibody
- Product Name
- Tuberin-Specific antibody
- Catalogue No.
- FNab09101
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- tuberous sclerosis 2
- Alternative Names
- FLJ43106 antibody, LAM antibody, TSC2 antibody, TSC4 antibody, Tuberin antibody, tuberous sclerosis 2 antibody, Tuberous sclerosis 2 protein antibody
- UniProt ID
- P49815
- Observed MW
- 200 kDa
Application
- Tested Applications
- ELISA, WB, IF, IHC
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:20-1:200；IF: 1:10-1:100
Validated Images
mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab09101(TSC2-Specific antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human kidney slide using FNab09101(TSC2-Specific Antibody) at dilution of 1:50
- Background
- TSC2, also named as TSC4, FLJ43106 and LAM, acts as a GTPase-activating protein(GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In complex with TSC1, TSC2 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. TSC2 implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. TSC2 stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Mutations in either TSC2 or the related TSC1(hamartin) gene cause tuberous sclerosis complex(TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. The antibody is specific to TSC2.
