Products
TTRAP antibody
- Product Name
- TTRAP antibody
- Catalogue No.
- FNab09098
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- TRAF and TNF receptor associated protein
- Alternative Names
- 5 Tyr DNA phosphodiesterase antibody, AD022 antibody, dJ30M3.3 antibody, EAP2 antibody, EAPII antibody, ETS1 associated protein 2 antibody, ETS1 associated protein II antibody, TDP2 antibody, TTRAP antibody, Tyr DNA phosphodiesterase 2 antibody
- UniProt ID
- O95551
- Observed MW
- 44 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:200-1:2000
Validated Images
human spleen tissue were subjected to SDS PAGE followed by western blot with FNab09098(TTRAP antibody) at dilution of 1:500
IP Result of anti-TTRAP (IP:FNab09098, 4ug; Detection:FNab09098 1:500) with mouse spleen tissue lysate 4800ug.
- Background
- TTRAP is a 5-prime tyrosyl-DNA phosphodiesterase that is required for efficient repair of topoisomerase II-induced DNA double-strand breaks. Thus it can remove lots of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, generating a free 5' phosphate to DNA. It also has 3'-tyrosyl DNA phophodiesterase activity, but not so efficient as TDP1. TTRAP functions as a negative regulator of ETS1 and inhibit nuclear factor-kappa-B activation.
