Products
TTI1 antibody
- Product Name
- TTI1 antibody
- Catalogue No.
- FNab09093
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- KIAA0406
- Alternative Names
- TELO2-interacting protein 1 homolog antibody, KIAA0406 antibody, SMG10 antibody, TTI1 antibody
- UniProt ID
- O43156
- Observed MW
- 122 kDa
Application
- Tested Applications
- ELISA, WB, IP
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:500-1:5000
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab09093(KIAA0406 Antibody) at dilution of 1:1000
IP Result of anti-TTI1 (IP:FNab09093, 4ug; Detection:FNab09093 1:1000) with HeLa cells lysate 1600ug.
- Background
- Regulator of the DNA damage response(DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase(PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation(IR), ultraviolet(UV) and mitomycin C(MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
