SH-SY5Y cells were subjected to SDS PAGE followed by western blot with FNab09014(TRPC1 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded mouse heart using FNab09014(TRPC1 antibody)at dilution of 1:100
Background
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.