Products
TRIM37 antibody
- Product Name
- TRIM37 antibody
- Catalogue No.
- FNab08982
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- tripartite motif-containing 37
- Alternative Names
- TRIM37 antibody, POB1 antibody, TEF3 antibody, MUL antibody, tripartite motif containing 37 antibody
- UniProt ID
- O94972
- Observed MW
- 100kDa, 130kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Validated Images
Mouse testis were subjected to SDS PAGE followed by western blot with FNab08982(TRIM37 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded mouse testis using FNab08982(TRIM37 antibody) at dilution of 1:100
Immunofluorescent analysis of MCF7 cells using FNab08982 (TRIM37 antibody) at dilution of 1:50 and FITC-conjugated Goat Anti-Rabbit IgG(H+L)
- Background
- E3 ubiquitin-protein ligase required to prevent centriole reduplication(PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication(PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A(H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group(PcG) multiprotein PRC2-like complex and mediates repression of target genes(PubMed:25470042). Has anti-HIV activity(PubMed:24317724).
