Products
TRIM24 antibody
- Product Name
- TRIM24 antibody
- Catalogue No.
- FNab08975
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- tripartite motif-containing 24
- Alternative Names
- HTIF1 antibody, PTC6 antibody, RING finger protein 82 antibody, RNF82 antibody, TF1A antibody, TIF1 antibody, TIF1 alpha antibody, TIF1A antibody, TIF1ALPHA antibody, TRIM24 antibody, tripartite motif containing 24 antibody
- UniProt ID
- O15164
- Observed MW
- 117 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IP
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200; IF: 1:50-1:500
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab08975(TRIM24 antibody) at dilution of 1:500
IP Result of anti-TRIM24 (IP:FNab08975, 4ug; Detection:FNab08975 1:800) with MCF-7 cells lysate 4000ug.
Immunohistochemistry of paraffin-embedded human prostate cancer using FNab08975(TRIM24 antibody) at dilution of 1:100
- Background
- Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4'(H3K4me0) and acetylated at 'Lys-23'(H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor(TR) and ESR1. Modulates transcription activation by retinoic acid(RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes(By similarity).
