A549 cells were subjected to SDS PAGE followed by western blot with FNab08972(TRIM21 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lung cancer using FNab08972(TRIM21 antibody) at dilution of 1:50
Background
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.