Products

TREX1 antibody

Synonyms:3 5 exonuclease TREX1 antibody, AGS1 antibody, AGS5 antibody, CRV antibody, DKFZp434J0310 antibody, DNase III antibody, DRN3 antibody, HERNS antibody, TREX1 antibody
Catalogue No.:FNab08963Reativity:Human
Host:RabbitTested Application:ELISA, WB, IP
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
TREX1 antibody
Catalogue No.
FNab08963
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
three prime repair exonuclease 1
Alternative Names
3 5 exonuclease TREX1 antibody, AGS1 antibody, AGS5 antibody, CRV antibody, DKFZp434J0310 antibody, DNase III antibody, DRN3 antibody, HERNS antibody, TREX1 antibody
UniProt ID
Q9NSU2
Observed MW
32 kDa
Application
Tested Applications
ELISA, WB, IP
Recommended dilution
WB: 1:200-1:1000; IP: 1:200-1:1000
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab08963(TREX1 Antibody) at dilution of 1:300
IP Result of anti-TREX1 (IP:FNab08963, 4ug; Detection:FNab08963 1:300) with HeLa cells lysate 1200ug.
Background
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA(ssDNA) and double-stranded DNA(dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA(ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.