Products

TOLLIP antibody

Synonyms:IL 1RAcPIP antibody, toll interacting protein antibody, TOLLIP antibody
Catalogue No.:FNab08854Reativity:Human, Mouse, Rat
Host:RabbitTested Application:ELISA, WB, IHC, IF
Clonality:polyclonalIsotype:IgG
  • SPECIFICATIONS
Product Name
TOLLIP antibody
Catalogue No.
FNab08854
Size
100μg
Form
liquid
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Clonality
polyclonal
Isotype
IgG
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
Immunogen
toll interacting protein
Alternative Names
IL 1RAcPIP antibody, toll interacting protein antibody, TOLLIP antibody
UniProt ID
Q9H0E2
Observed MW
30 kDa
Application
Tested Applications
ELISA, WB, IHC, IF
Recommended dilution
WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:20-1:100
Validated Images
PC-3 cells were subjected to SDS PAGE followed by western blot with FNab08854(TOLLIP antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human gliomas using FNab08854(TOLLIP antibody) at dilution of 1:100
Immunofluorescent analysis of PC-3 cells using FNab08854 (TOLLIP antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L)
Background
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity(PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates(PubMed:25042851).