HeLa cells were subjected to SDS PAGE followed by western blot with FNab08816(TNFAIP1 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human placenta using FNab08816(TNFAIP1 antibody) at dilution of 1:50
Background
Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.